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toggletext-ed from Indonesian:
Bird flu and Elfahmi Medicine plants
Oct 2, 2006
Elfahmi
The Researcher Indonesian Medicine plants and the Lecturer the Bandung School of the Pharmacy of the technological Institute
Bird flu made all the sides concerned. The official of the related country made an effort to look for the solution took the form of preventive efforts and medical treatment. The mass media then incessantly reported this case so as to become the big case. Therefore efforts to oppose this illness could be maximal. However apparently the response to this bird flu descended.
The spreading concern of this bird flu not only happened in Indonesia. Several countries in Europe then have carried out the prevention action of the entry of the bird flu virus. When the poultry in the south Turki area positive terjangkit bird flu, the Dutch Government at once banned the entry of the poultry to the Netherlands by any means. The available poultry in the Netherlands dikarantina. Tens of thousands of Tamiflu tablets had as bird flu medicine been ordered and prepared.
It was not doubtful that a mother was named Sulastri including concerned and want to berkontribusi by treating the bird flu patient. Had a supply of traditional medical treatment knowledge that was owned hereditary, Sulastri cut medicine by the name of proflub and was claimed by him could cure the bird flu illness (detik.com 27/09/2005). The Sulastri claim of bird flu medicine was then denied by Health Minister, Siti Fadil -lah Supari.
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If seeing the process that must be passed through for the discovery of medicine, then what was revealed by the Health Minister could be really understood and true the existence. To become a medicine, the chemical compound or the remedy must through the research and the testing that was long enough. Finally after through the clinical test, if this medicine filled the condition, just could be said a medicine.
On the other hand Sulastri courage also had the background that he understood that proflub that consisted of the mixture of medicine plants that has been proven had the usefulness. Proflub contained the Acorus mixture calamus, Coriandri fructus, Coleus scutellarioides, Zingiber americonus, and Phyllanthus niruri (not Plaglantu niruri like that was written detik.com).
Paid close attention to this Sulastri claim the writer also be reminded when becoming an epidemic him dengue fever dengue fever (DBD) in the Motherland some time before. Circulated information widely especially through the internet that medicine plants that one of his components meniran (Phyllanthus niruri), also could treat the illness DBD. some information was supplemented with the testimony of several people who have tried him.
The phenomenon of the use of these medicine plants interesting to be paid close attention to, berhubung Indonesia was the country that had the biggest biological diversity second in the world after Brazil. To understand Sulastri courage better we must know medicine plants that were made the component proflub. The five plants were recorded in the Indonesian index of medicine plants that was published by PT Eisai Indonesia (1995). Pulled him again, the five of them were also used as the herbal tonic component for various aims of medical treatment.
Three tanaman
Below this was seen by us the short analysis three from five crops. Acorus calamus complete him named Acorus calamus L var verus L. this Crop had the different vernacular name, like Jerengee (Aceh), Jerangau (Minang), Dringo (Java), et cetera. These plants were used by the community as fever medicine, the cough, the ulcer, and expedited the circulation of blood. Acorus calamus also was used as incentive medicine by the original North American inhabitants that they mentioned with coca from the north but also grew in Europe. Until this at least had approximately 170 scientific researches about these plants that dipublikasi to regional and international journals.
It did not yet have the report on the research about the direct usefulness of these plants towards the virus avian influenza (H5N1) that was found as the cause of bird flu. The usefulness of the increase in body immunity had the reason that was rational enough if considering these plants could be used to treat the bird flu illness. However must be done by the further research.
Coriandri fructus was from Coriandrum plants sativum L that really was known in Indonesia and often to be used by the community for the cooked spice. Coriander, this plants vernacular name, also entered the remedy guidebook in America (USP; United State Pharmacopea) and in England (The Bristish Pharmacopea Codex). Traditionally was used for medical treatment of side pain, had a headache, medicine penahan vomited, the thrush, as well as the disturbance of menstruation.
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That following was Phyllanthus niruri. These plants were known by the name of meniran, and often was used to the traditional medicine component or the herbal tonic. Traditionally meniran was used by the community to treat the illness was difficult to urinate, asthma, hepatitis, malaria, and to antivirus. This traditional use including being proven scientifically with the research in the laboratory. Meniran it was known had the role hindered the entry of calcium oksalat (the cause compound was difficult urine) in the research that was carried out in 2002.
The effect antimalaria from these plants also was reported hindered the Plasmodium growth falsiparum, a kind of cause parasite of malaria. Meniran has also been researched by his anti-cancer effect by means of increasing the system of body immunity. Many other researches that proved the usefulness from plants meniran this was good in a manner in vitro (the beginning stage of the activity research of the remedy), in vivo, and the clinical test as the level of the research that higher. Moreover meniran has been made the Indonesian nature remedy the kind fitofarmaka (the usefulness claim has been based on the clinical test and was guaranteed by his security).
The chemical compound that it was suspected gave the usefulness also has been isolated from these plants among them the group of the compound liganan like filantin, hipofilantin, et cetera. Was based on traditional information and his authentication in a manner the laboratory with the activity antivirus and menstimulan the response of body immunity, these plants that closest his connection was with the prospect made the remedy for bird flu and the similar illness.
Tamiflu, at this time was the only medicine that direkomendaasikan by WHO to overcome bird flu. This medicine was marketed by the Roche pharmacy company. Tamiflu contained the chemical compound that was given by the name oseltamifir. Oseltamifir worked as the obstacle to the work of protein neuraminidase, so as to prevent the growth of the virus to the foster-mother's cell (in the case of bird flu was the cell to humankind).
Oseltamifir as the raw material tamiflu that is used now was results of the organic synthesis with several reaction stages of chemistry. At least had 12 reaction stages of chemistry with the beginning material of acid sikimat. The acid compound sikimat this that often was found to plants. Several other remedies that came from plants also were made with the beginning material of acid sikimat this. If being seen from the structure of chemistry, oseltamifir was not the impossible matter to cut off the reaction stages of this chemistry with the other beginning material that came from the crop.
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The writer took three examples of the crop that was put forward by this Sulastri only want to explained that Indonesian medicine plants had the potential that very big to be developed. Other medicine plants that was researched by the activity antivirus him also still many like sambiloto, mahogany, turmeric. Pulled him, some researches were carried out by the researcher in the other country.
Paid close attention to available medicine plants in Indonesia that was used traditionally to treat the illness that was caused by the virus, actually Indonesian medicine plants could be developed for bird flu medicine and the illness that were caused by the other virus. Several questions emerged afterwards, could we develop the laboratory that could be used to research medicine antivirus with all the risks of his security? Indonesian researchers already serious worked on the rich natural resources this for the interests of the health of the community?
Ikhtisar
- spread him bird flu stimulated the person to find medicine barbasis plants that could overcome him.
- the temporary findings bird flu medicine still could not be from inside the country acknowledged juridically formal.
- Indonesia kept many biological wealth that could be developed for the prevention of bird flu.
http://www.republika.co.id/kolom_detail.asp?id=266779&kat_id=16
The herb is showing some great potential in both herpes and chronic Hep B infections. It appears to have some toxicity, however. I would not suggest anyone use this without being under the care of a qualified medical professional who will monitor reactions.
http://www3.interscience.wiley.com/cgi-bin/abstract/112161708/ABSTRACT
Research Article
Some clinico-pathological changes associated with the aqueous extract of the leaves of Phyllanthus amarus in rats
| | A. A. Adedapo 1 *, A. Y. Adegbayibi 1, B. O. Emikpe 2 | 1Department of Veterinary Physiology and Pharmacology, University of Ibadan, Ibadan, Nigeria
2Department of Veterinary Pathology, University of Ibadan, Ibadan, Nigeria
| | email: A. A. Adedapo (adedapo3a@yahoo.co.uk) |
*Correspondence to A. A. Adedapo, Department of Veterinary Physiology and Pharmacology, University of Ibadan, Ibadan, Nigeria.
| pathology • haematology • serum biochemistry • Phyllanthus amarus |
| The pathological changes of the aqueous crude extract of the leaves of Phyllanthus amarus were studied in 32 male rats over a period of 30 days. The animals were divided into four groups of eight animals per group. The aqueous crude extract was prepared and administered orally using a cannula to rats in three groups receiving doses of 400 mg/kg, 800 mg/kg and 1000 mg/kg but the fourth group served as a control and received distilled water only. Blood samples were collected for haematological and serum biochemical analysis. Organs such as the liver, kidney, testes and pancreas were also assessed for histopathological changes. The study showed that the extract caused a decrease in the red blood cell (RBC) count, packed cell volume (PCV), haemoglobin concentration (Hb), but an increase in the white blood cell (WBC) count. The extract also resulted in an increase in the levels of aspartate amino transferase (AST), total and conjugated bilirubin, total protein and albumin. The study, however, caused a decrease in the level of alanine amino transferase (ALT). Histopathologically, there were cases of protein casts in the kidney tubules with tubular nephrosis, foci of lymphocytic infiltration at the portal areas of the liver as well as marked testicular degeneration with severe disorganization of seminiferous tubules, which were devoid of spermatic cells. A reduction in the weight of the experimental animals was also noted in this study. It thus shows that Phyllanthus amarus has potential toxic properties. © 2005 John Wiley & Sons, Ltd. |
Received: 4 April 2005; Accepted: 18 August 2005
| Digital Object Identifier (DOI) |
10.1002/ptr.1768 About DOI (http://www3.interscience.wiley.com/doiinfo.html)
Ditto on that!
I know of the alternative medical properties of calamas root and coriander but the third, Phyllanthus niruri, is a new one. I will have to do a little research to see what I can find to back up the allegations. Thanks Theresa.
It looks like it is being investigated primarily for liver disorders. Full text article is availble see bottom of page.
http://www.blackwell-synergy.com/links/doi/10.1046/j.1440-1746.17.s3.30.x
Journal of Gastroenterology and Hepatology
Volume 17 Page S370 - December 2002
doi:10.1046/j.1440-1746.17.s3.30.x
| | Volume 17 Issue s3 | | | | CONFERENCE PROCEEDINGS | | Herbal medicines for liver diseases in India | SP THYAGARAJAN, S JAYARAM, V GOPALAKRISHNAN, R HARI, P JEYAKUMAR AND MS SRIPATHI
| Abstract The use of natural remedies for the treatment of liver diseases has a long history, starting with the Ayurvedhic treatment, and extending to the Chinese, European and other systems of traditional medicines. The 21st century has seen a paradigm shift towards therapeutic evaluation of herbal products in liver diseases by carefully synergizing the strengths of the traditional systems of medicine with that of the modern concept of evidence-based medicinal evaluation, standardization of herbal products and randomized placebo controlled clinical trials to support clinical efficacy. The present review provides the status report on the scientific approaches made to herbal preparations used in Indian systems of medicine for the treatment of liver diseases. In spite of the availability of more than 300 preparations for the treatment of jaundice and chronic liver diseases in Indian systems of medicine using more than 87 Indian medicinal plants, only four terrestrial plants have been scientifically elucidated while adhering to the internationally acceptable scientific protocols. In-depth studies have proved Sylibum marianum to be anti-oxidative, antilipidperoxidative, antifibrotic, anti-inflammatory, immunomodulating and liver regenerative. Glycyrrhiza glabra has been shown to be hepatoprotective and capable of inducing an indigenous interferon. Picrorhiza kurroa is proved to be anti-inflammatory, hepatoprotective and immunomodulatory. Extensive studies on Phyllanthus amarus have confirmed this plant preparation as being anti-viral against hepatitis B and C viruses, hepatoprotective and immunomodulating, as well as possessing anti-inflammatory properties. For the first time in the Indian systems of medicine, a chemo-biological fingerprinting methodology for standardization of P. amarus preparation has been patented.
© 2002 Blackwell Publishing Asia Pty Ltd
| | | http://www.blackwell-synergy.com/templates/jsp/_synergy/images/References_btn.gif (http://www.blackwell-synergy.com/doi/ref/10.1046/j.1440-1746.17.s3.30.x) http://www.blackwell-synergy.com/templates/jsp/_synergy/images/full_article_btn3.gif (http://www.blackwell-synergy.com/doi/full/10.1046/j.1440-1746.17.s3.30.x) http://www.blackwell-synergy.com/templates/jsp/_synergy/images/full_article_pdf_btn3.jsp?text=[90KB] (http://javascript:newWindow('/doi/pdf/10.1046/j.1440-1746.17.s3.30.x')) |
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7561442&dopt=Citation
| 1: J Lab Clin Med. (javascript:AL_get(this, 'jour', 'J Lab Clin Med.');) 1995 Oct;126(4):350-2. | Related Articles, (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=pubmed_Citation&db=pubmed&cmd=Display&dopt=pubmed_pubmed&from_uid=7561442&itool=ExternalSearch) Links (javascript:PopUpMenu2_Set(Menu7561442);) |
Herbs of the genus Phyllanthus in the treatment of chronic hepatitis B: observations with three preparations from different geographic sites.
Wang M (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Citation&term=%22Wang+M%22%5BAuthor%5D), Cheng H (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Citation&term=%22Cheng+H%22%5BAuthor%5D), Li Y (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Citation&term=%22Li+Y%22%5BAuthor%5D), Meng L (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Citation&term=%22Meng+L%22%5BAuthor%5D), Zhao G (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Citation&term=%22Zhao+G%22%5BAuthor%5D), Mai K (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Citation&term=%22Mai+K%22%5BAuthor%5D).
Henan Institute of Medical Sciences, Henan Medical University, People's Republic of China.
It has been suggested that herbs of the Phyllanthus family may have antiviral activity. We therefore tested the effects of three different Phyllanthus extracts on the serologic status of 123 patients with chronic hepatitis B. Eleven patients received an extract of Phyllanthus amarus (L) provided by S.P. Thyagarajan, Madras, India. Forty-two patients received Phyllanthus niruri (L), gathered from Hainan Province in China, and 35 patients received an extract of Phyllanthus urinaria (L), which had been gathered in Henan Province. Thirty-five control patients received no herbal therapy. The patients receiving Phyllanthus urinaria (L) were both more likely to lose detectable hepatitis B e-antigen from their serum and more likely to seroconvert hepatitis B e-antibody status from negative to positive than were patients given either of the other two preparations. No patient changed status with respect to hepatitis B s-antigen.
Publication Types:
Clinical Trial (javascript:AL_get(this, 'ptyp', 'Clinical Trial');)
Controlled Clinical Trial (javascript:AL_get(this, 'ptyp', 'Controlled Clinical Trial');)
MeSH Terms:
Adult (javascript:AL_get(this, 'mesh', 'Adult');)
Angiosperms* (javascript:AL_get(this, 'mesh', 'Angiosperms*');)
Antiviral Agents* (javascript:AL_get(this, 'mesh', 'Antiviral Agents*');)
China (javascript:AL_get(this, 'mesh', 'China');)
Chronic Disease (javascript:AL_get(this, 'mesh', 'Chronic Disease');)
Comparative Study (javascript:AL_get(this, 'mesh', 'Comparative Study');)
Drugs, Chinese Herbal (javascript:AL_get(this, 'mesh', 'Drugs, Chinese Herbal');)
Female (javascript:AL_get(this, 'mesh', 'Female');)
Geography (javascript:AL_get(this, 'mesh', 'Geography');)
Hepatitis B/blood (javascript:AL_get(this, 'mesh', 'Hepatitis B/blood');)
Hepatitis B/therapy* (javascript:AL_get(this, 'mesh', 'Hepatitis B/therapy*');)
Hepatitis B e Antigens/blood (javascript:AL_get(this, 'mesh', 'Hepatitis B e Antigens/blood');)
Humans (javascript:AL_get(this, 'mesh', 'Humans');)
India (javascript:AL_get(this, 'mesh', 'India');)
Male (javascript:AL_get(this, 'mesh', 'Male');)
Plants, Medicinal* (javascript:AL_get(this, 'mesh', 'Plants, Medicinal*');)
Substances:
Antiviral Agents (javascript:AL_get(this, 'subs', 'Antiviral Agents');)
Drugs, Chinese Herbal (javascript:AL_get(this, 'subs', 'Drugs, Chinese Herbal');)
Hepatitis B e Antigens (javascript:AL_get(this, 'subs', 'Hepatitis B e Antigens');)
Thanks, Shannon! I knew you'd know where to look for pertinent info -- as I also knew you'd have something intelligent and informed to say on these medicinal plants!
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